Elena Lacosta, a paranoid, take-no-prisoners drug trafficker turned FBI fugitive, marries a cop and fights her inner demons; her new life depends on it.

When Elena's oldest brother Gabriel is killed, she listens to what seems like endless accolades about him at his memorial service, held in a packed church with standing room only; and before the dirt on his grave can settle, she is scheming to reinvent herself in her dead brother's image to launch her new life.

Elena plants rumors about another brother, Tomas, a college professor with Asperger's whom she views as a threat to her new image and life. When she falsely accuses him of pedophilia, Tomas turns family detective and unknowingly crosses paths with an undercover FBI agent who is hot on Elena's trail for the murder of his half-brother twelve years earlier-and Elena's carefully constructed mask begins to unravel.

It is a story that is also told through the violent and parallel struggle of a young boy in Rome in the year 1400, who began the ancient Order of Octavius to battle corruption. These two stories collide in present-day San Simone with the arrival of the mysterious Father Argus, an envoy from the Vatican. But is Father Argus trying to stop Gil or recruit him? The ultimate answer is only revealed in the aftermath of the Pope's final bloody telekinetic assault, a supernatural blood bath that leaves a trail of guilty bodies in its wake.