In 1984, in the small Brazilian village of Promissão, a young child begins to fuss, her eyes turning pink and her skin flushed with heat. Four days later, she's dead.

Sidonie Royal, an accomplished physician and scientist, arrives in the small Brazilian village of Promissão to investigate and hopefully cure this insidious new disease. With several young children already dead, and more getting sick by the day, the stakes cannot get any higher. But Sid's personal life is also in flux, as she struggles to balance a complicated relationship with her boyfriend, Paul, pressure to start a family from her well-meaning mother, conflict with her surly but brilliant coworker named Eliot, and a budding romantic attraction to her doctoral student's twin brother.

As Sid relentlessly pursues an explanation for the disease, the village's physician calls in the Global Health Agency, triggering a scientific race that spans two continents and becomes increasingly defined by personal stakes. In a desperate attempt to determine a diagnosis for the disease, Sid sneaks a vial of an infected child's blood back to her lab in Michigan. As her personal life and romantic relationships fall apart, she becomes consumed by her desire to win the medical race against the GHA. However, her volatile (and sometimes emotional) relationship with Eliot will hinder her as much as it will help her on her journey for discovery.

Set against the backdrop of the early days of the AIDS epidemic, Fever is about finding courage in the face of the unknown, the lasting power of community, and one woman's challenge to prove herself as she aims to make a life-saving--and career-defining--discovery.